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Antimicrobial resistance (AMR) presents a major global health threat, particularly at the interface of human and animal health. Escherichia coli is a key indicator organism for AMR surveillance and is commonly found in both humans and pigs. Pigs are recognized as significant reservoirs of antibiotic resistance genes (ARGs), facilitating the potential transmission of resistant bacteria to humans. This study aimed to systematically review ARG profiles and associated phenotypic resistance in E. coli isolates from human and pig sources using whole-genome sequencing (WGS) data.