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This could help doctors prescribe medicines to have the best intended effect by syncing the dosing up with the natural clocks of their patients. Having taken that step, doctors could now turn to the model to help predict the impact of the dose and timing of drugs with similar modes of action, Yao said. The team showed that the effects of modafinil can vary markedly depending on whether a person takes the drug in rhythm or not. How it works isn't fully understood, but the team's model, which showed how DRIs lengthened each cycle of this ultradian rhythm, could also help provide information to solve this question of fundamental biology, he said.