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AlphaFold is five years old — these charts show how it revolutionized science

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Abstract

The 2021 release of AlphaFold2's code and a database that has swelled to hundreds of millions of predicted structures mean that scientists can now get a reliable prediction for almost any protein. It's like the second coming of structural biology." Rapid discovery For Pauli's team, the software shone a light on a path they might otherwise never have found. DeepMind's John Jumper — who shared half of the 2024 Nobel Prize in Chemistry with chief executive Demis Hassabis for developing AlphaFold — says he is "deeply proud" of how useful the tool has been for scientists such as Pauli. Researchers who used AlphaFold submitted around 50% more protein structures to a repository of experimental models, called the Protein Data Bank (PDB), than did a non-AlphaFold-using 'baseline' of structural-biology researchers, finds a Google DeepMind-funded study of AlphaFold's impacts released this week."
Key Data

  • Publication Date
    26 November 2025
  • Primary Author
    Ewen Callaway
  • Source
    Nature
  • Language
    English
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