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It wasn't a wild celebration with masses on the streets, nor was it widely celebrated in universities, but rather a quiet admiration by people in the field for one of the cornerstone methods that has advanced our understanding of many processes at the molecular scale. FCS began to shine with the availability of confocal microscopes in the 1990s and has since been actively used to study chemical reactions, formation of aggregates, molecular movements in cells, and attachment of molecules to membranes, to name a few applications. In a confocal microscope, a laser is focused on the sample, whether it's a cell or other object, and the signal is collected only from the very small volume at the laser's focus. About six years ago, a research group in the U.S. proposed an alternative approach: dropping autocorrelation from the analysis and using mathematical models that work directly with the noisy experimental data to extract the same information as from FCS.