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The golden age of discovery is over and the way we develop and use drugs needs to change During her tenure as director general of the World Health Organization, Dr Margaret Chan used to say that all of the easy" antibiotics had already been found. One of the new drugs, Zoliflodacin, is the product of a novel kind of partnership between the Swiss non‑profit Global Antibiotic Research and Development Partnership (GARDP) and the pharmaceutical company Innoviva. This approach and the UK government's lauded "subscription model" – launched in 2022 to guarantee revenue to companies that invested in certain antibiotics – represent the best hope of maintaining a dripfeed of new drugs out of the current system. Zoliflodacin is sometimes described as a new class of antibiotics, meaning one that targets a part of the infectious bacteria that no other drug does, theoretically forcing the pathogen to start from zero in evolving a countermeasure to it."