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However, in almost a third of sepsis patients, doctors can't find the specific pathogen causing the problem, which makes it hard to choose the right treatment When a pathogen is identified, it is often among the usual suspects" such as Klebsiella pneumoniae, Escherichia coli, or methicillin-resistant Staphylococcus aureus (MRSA). Time to treatment for sepsis is critical for a patient's survival, the longer it takes to give the first dose of antibiotics, the higher the risk of death. This creates an inherent tension: patients may initially not receive the most optimal therapy because the levels and types of drug resistance cannot be identified quickly enough, by the time treatment is adjusted, the delay can significantly increase the risk of death. The Challenge of Change: Why Adoption Isn't Easy Implementing changes, such as focussing on earlier diagnosis, within a healthcare system is complex and multifaceted, with numerous requirements and barriers to the adoption of novel diagnostic tools. Taking STRIDES to capture the full impact of AMR diagnostics The Office of Health Economics (OHE) has recently developed a new value framework to highlight the benefits of diagnostics in combatting AMR."