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As climate change accelerates the melting of glaciers around the world, scientists are warning of a little-known risk flowing downstream with the meltwater: antibiotic resistance genes that have been locked in ice for thousands of years. Although resistance levels in glaciers are generally lower than in heavily polluted environments, the review shows that a wide variety of resistance genes have been detected, including those linked to clinically important antibiotics. Rather than treating glaciers, rivers, and lakes as separate environments, the researchers argue they should be understood as a connected system through which resistance genes are transported, transformed, and potentially amplified. The findings underscore the importance of viewing antibiotic resistance through a One Health lens that connects environmental change, ecosystem integrity, and public health in a warming world.