Abstract
The One Health joint plan of action (2022–2026) of the WHO, the Agriculture Organization of the United Nations (FAO), the World Organization for Animal Health (WOAH), and the (United Nations Environment Programme UNEP) was established as a quadripartite cooperation. The updated list identifies 24 bacterial pathogens of greatest concern, with the aim of addressing the evolving challenges of AMR and guiding priorities in research, the development of new antimicrobials, and public health interventions [11]. Wanda et al. also found an increase in ICU mortality due to AMR bacterial infection: OR 1.65 (95% CI 1.18–2.43), without making a distinction between the type of infection [26], Hixon et al. calculated a median excess mortality difference of 5.8% (IQR: 2.6–4.0%) in cases of AMR Gram-negative bacterial pneumonia [27], and Nelson et al. reported mortality attributable to health care-associated infections due AMR organisms of 4.9% for AMR Gram-negative bacteria and 5.9% for MRSA [28]. We applied rigorous exclusion criteria (Figure 4) to the study sample—including the elimination of pneumonia cases without microbiological isolation, the exclusion of polymicrobial infections, and the exclusion of patients with another concomitant bacterial infection in addition to pneumonia—in order to minimize bias when comparing populations with similar clinical characteristics.
Key Data
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Publication Date10 October 2025
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Primary AuthorIván Oterino-Moreira
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SourceMDPI
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LanguageEnglish
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