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Despite the well-described association of skin lesions with Staphylococcus aureus, the distinct ability of clinical isolates to influence the local and systemic inflammatory response in a patient-specific manner is insufficiently characterized, writes Dr. Anne Jamet, lead author of the research. The immune system's response to infection The situation is made all the more difficult in RDEB by the way the bacterial disease hijacks the immune system with elevated activity of at least two key immune system components in severe disease. Study design and key findings To find out what goes awry in the immune system of those with RDEB, allowing S. aureus to sustain colonization in the mouth, on the hands and feet, or any tissue of children with RDEB, the team of scientists designed and carried out a clinical trial. The genetic fragility of the skin of patients with RDEB combined with immune response anomalies result in chronic wounds that are chronically infected by S. aureus," Jamet explained in the research paper."