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Assessing the health burden of infections with antibiotic-resistant bacteria in the EU/EEA, 2016-2020 Annex 1: Estimated number of infections, number of attributable deaths and number of disability-adjusted life-years per 100 000 population, EU/EEA, 2016-2020 Table S1-1: Estimated number of infections with antibiotic -resistant bacteria, EU/EEA, 2016-2020 (by decreasing number of infections in 2020) 2016 2017 2018 2019 2020 Third-generation cephalosporin- resistant E. coli 196 202 (170 928 - 224 100) 206 649 (179 936 - 235 812) 237 020 (205 915 - 271 169) 243 588 (211 927 - 278 726) 203 909 (177 480 - 233 237) Meticillin-resistant S. aureus 170 713 (146 818 - 197 243) 168 240 (144 697 - 194 216) 195 287 (168 058 - 225 638) 187 378 (161 303 - 216 273) 159 670 (137 179 - 184 632) Vancomycin- resistant E. faecalis / E. faecium 47 124 (36 533 - 59 549) 58 009 (44 902 - 73 502) 79 919 (61 654 - 101 378) 99 184 (76 809 - 125 604) 117 866 (91 969 - 148 215) Third-generation cephalosporin- resistant K. pneumoniae 106 230 (95 547 - 117 703) 108 166 (97 247 - 119 877) 128 787 (115 762 - 142 771) 136 861 (122 759 - 151 949) 116 620 (104 445 - 129 686) Carbapenem- resistant Acinetobacter spp. 3 509 (2 887 - 4 204) 3 183 (2 662 - 3 765) 2 414 (1 969 - 2 914) 3 009 (2 459 - 3 631) 2 201 (1 799 - 2 650) Carbapenem- resistant E. coli 1 015 (796 - 1 278) 1 086 (863 - 1 367) 1 641 (1 350 - 1 978) 4 094 (3 452 - 4 833) 1 987 (1 662 - 2 361) Overall 685 433 (589 451 - 792 873) 701 816 (603 052 - 811 925) 822 075 (706 070 - 951 816) 865 767 (742 802 - 1 003 591) 801 517 (684 955 - 932 213) Table S1-2: Estimated number of attributable deaths due to infections with antibiotic -resistant bacteria, EU/EEA, 2016-2020 (by decreasing number of attributable deaths in 2020) 2016 2017 2018 2019 2020 Third-generation cephalosporin- resistant E. coli 8 715 (7 703 - 9 783) 9 181 (8 113 - 10 305) 10 552 (9 310 - 11 870) 10 841 (9 567 - 12 197) 9 079 (8 015 - 10 211) Meticillin-resistant S. aureus 6 889 (6 208 - 7 641) 6 789 (6 123 - 7 529) 7 917 (7 141 - 8 783) 7 574 (6 833 - 8 392) 6 463 (5 823 - 7 172) Third-generation cephalosporin- resistant K. pneumoniae 4 256 (3 976 - 4 555) 4 346 (4 056 - 4 657) 5 185 (4 839 - 5 556) 5 526 (5 149 - 5 929) 4 714 (4 386 - 5 064) Carbapenem- resistant K. pneumoniae 2 770 (2 415 - 3 125) 2 598 (2 274 - 2 926) 3 278 (2 862 - 3 695) 3 853 (3 363 - 4 347) 4 076 (3 565 - 4 585) Carbapenem- resistant Acinetobacter spp. 2 395 (1 928 - 2 875) 2 464 (2 014 - 2 932) 2 484 (2 070 - 2 909) 2 749 (2 294 - 3 211) 3 656 (3 036 - 4 289) Vancomycin- resistant E. faecalis / E. faecium 1 335 (1 193 - 1 501) 1 645 (1 471 - 1 854) 2 314 (2 063 - 2 608) 2 876 (2 565 - 3 242) 3 414 (3 052 - 3 834) Carbapenem- resistant P. aeruginosa 3 091 (2 446 - 3 821) 2 867 (2 260 - 3 555) 3 325 (2 628 - 4 112) 3 433 (2 707 - 4 252) 3 210 (2 513 - 4 004) Multidrug-resistant P. aeruginosa 386 (279 - 518) 393 (284 - 526) 471 (353 - 610) 492 (367 - 638) 362 (266 - 476) Penicillin-non-wild- type and macrolide-resistant S. pneumoniae 390 (360 - 427) 359 (331 - 393) 455 (420 - 496) 508 (470 - 553) 301 (277 - 329) Penicillin-non-wild- type S. pneumoniae 260 (239 - 287) 301 (278 - 330) 379 (350 - 413) 390 (361 - 425) 276 (254 - 303) Carbapenem- resistant E. coli 79 (62 - 98) 86 (67 - 105) 130 (105 - 155) 324 (269 - 380) 157 (129 - 185) Aminoglycoside- and fluoroquinolone- resistant Acinetobacter spp. 164 (126 - 205) 149 (117 - 184) 115 (86 - 145) 144 (108 - 182) 105 (79 - 132) Overall 30 730 (26 935 - 34 836) 31 178 (27 388 - 35 296) 36 605 (32 227 - 41 352) 38 710 (34 053 - 43 748) 35 813 (31 395 - 40 584) Table S1-3: Estimated number of disability -adjusted life-years (DALYs) due to infections with antibiotic - resistant bacteria, EU/EEA, 2016-2020 (by decreasing number of DALYs in 2020) 2016 2017 2018 2019 2020 Third-generation cephalosporin- resistant E. coli 215 092 (196 334 - 234 529) 223 684 (204 159 - 243 818) 251 866 (229 483 - 275 078) 256 825 (234 192 - 280 215) 216 440 (197 539 - 236 012) Meticillin-resistant S. aureus 187 520 (172 768 - 203 664) 185 405 (170 676 - 201 539) 209 693 (193 338 - 227 652) 204 729 (189 022 - 221 905) 170 581 (157 100 - 185 491) Third-generation cephalosporin- resistant K. pneumoniae 148 158 (139 698 - 157 182) 145 479 (137 285 - 154 206) 169 097 (159 534 - 179 229) 172 365 (162 413 - 182 882) 145 761 (137 308 - 154 739) Carbapenem- resistant K. pneumoniae 84 166 (74 063 - 94 339) 79 274 (70 282 - 88 340) 97 757 (86 724 - 108 799) 113 493 (100 650 - 126 231) 123 253 (109 534 - 136 941) Carbapenem- resistant Acinetobacter spp.