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By comparing resistance data from multiple surveillance systems, the researchers identified alarming trends: rising resistance to last-line antibiotics, regional disparities, and the rapid spread of resistant genes through global travel and agriculture. A research team from Jilin University and Peking Union Medical College Hospital has issued a comprehensive review in the Medical Journal of Peking Union Medical College Hospital. By revealing the molecular mechanisms and treatment challenges of AMR, it provides a scientific foundation for global action and highlights how strategic antibiotic use could slow the tide of resistance. In response, the authors recommend individualized treatment guided by pharmacokinetic and pharmacodynamic data, including the use of β-lactamase inhibitors, tigecycline, and polymyxin-based combinations.